Structure-function relationships of plant lectins that specifically recognize T and Tn antigens
نویسندگان
چکیده
† Surfa ces Cellulaires et Signalisation chez les Végétaux, UMR UPS-CNRS 5546, Pôle de Biotechnologie végétale, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France § Ghent University, Department of Molecular Biotechnology, Laboratory of Biochemistry and Glycobiology, Coupure Links 653, 9000 Gent, Belgium ¶ Glyco-Immunochemistry Research Laboratory, Institute of Molecular and Cellular Biology, College of Medicine, Chang-Gung University Kwei-San, Tao-Yuan, 333, Taiwan ‡ Funding by the Centre National de la Recherche Scientifique is acknowledged
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Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Prognosis and Therapy
Aberrant O-glycans expressed at the surface of cancer cells consist of membrane-tethered glycoproteins (T and Tn antigens) and glycolipids (Lewis a, Lewis x and Forssman antigens). All of these O-glycans have been identified as glyco-markers of interest for the diagnosis and the prognosis of cancer diseases. These epitopes are specifically detected using T/Tn-specific lectins isolated from vari...
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